RXN-13733

Reaction RXN0-2921

• direction:
  • LEFT-TO-RIGHT
• common name:
  • folylpolyglutamate_synthase
  • bifunctional_protein
• ec number:
  • EC-6.3.2.17
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 GLT[c] + 1 METHYLENE-THF-GLU-N[c] + 1 ATP[c] => 1 ADP[c] + 1 Pi[c] + 1 METHYLENE-THF-GLU-N[c]
• With common name(s):
  • 1 L-glutamate[c] + 1 a 5,10-methylene-tetrahydrofolate[c] + 1 ATP[c] => 1 ADP[c] + 1 phosphate[c] + 1 a 5,10-methylene-tetrahydrofolate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Tiso_gene_92
  • IN-SILICO_ANNOTATION
    • EC-NUMBER
  • pantograph-esiliculosus
• Tiso_gene_15942
  • IN-SILICO_ANNOTATION
    • EC-NUMBER

Pathways

• PWY-2161, folate polyglutamylation: PWY-2161
  • 5 reactions found over 5 reactions in the full pathway

Reconstruction information

• orthology:
  • pantograph:
    • esiliculosus
• annotation:
  • pathwaytools:
    • in-silico_annotation