Tiso gene 14345

Reaction PROGESTERONE-5-ALPHA-REDUCTASE-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • 3-oxo-5-alpha-steroid_4-dehydrogenase
• ec number:
  • EC-1.3.1.22
• Synonym(s):
  • steroid 5-α-reductase
  • Δ4-steroid 5α-reductase (progesterone)

Reaction Formula

• With identifiers:
  • 1 PROGESTERONE[c] + 1 PROTON[c] + 1 NADPH[c] => 1 NADP[c] + 1 CPD-293[c]
• With common name(s):
  • 1 progesterone[c] + 1 H+[c] + 1 NADPH[c] => 1 NADP+[c] + 1 5-α-pregnane-3,20-dione[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Tiso_gene_14327
  • IN-SILICO_ANNOTATION
    • AUTOMATED-NAME-MATCH

Pathways

• PWY-6032, cardenolide biosynthesis: PWY-6032
  • 1 reactions found over 3 reactions in the full pathway
• PWY-7455, allopregnanolone biosynthesis: PWY-7455
  • 1 reactions found over 2 reactions in the full pathway

Reconstruction information

• annotation:
  • pathwaytools:
    • in-silico_annotation

External links

• RHEA:
  • 21952
• LIGAND-RXN:
  • R02208