1.2.4.4-RXN

Reaction 1.2.4.4-RXN

• direction:
  • REVERSIBLE
• common name:
  • 3-methyl-2-oxobutanoate_dehydrogenase
  • 2-oxoisovalerate_dehydrogenase_alpha_subunit_mitochondrial
• ec number:
  • EC-1.2.4.4
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 BCAA-dehydrogenase-lipoyl[c] + 1 2-KETO-ISOVALERATE[c] + 1 PROTON[c] <=> 1 BCAA-dehydrogenase-2MP-DH-lipoyl[c] + 1 CARBON-DIOXIDE[c]
• With common name(s):
  • 1 an [apo BCAA dehydrogenase E2 protein] N6-lipoyl-L-lysine[c] + 1 3-methyl-2-oxobutanoate[c] + 1 H+[c] <=> 1 an [apo BCAA dehydrogenase E2 protein] N6-S-[2-methylpropanoyl]dihydrolipoyl-L-lysine[c] + 1 CO2[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Tiso_gene_11793
  • Source: annotation-in-silico_annotation
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: Tiso_gene_3260
  • Source: annotation-in-silico_annotation
    • Assignment: EC-NUMBER
  • Source: annotation-experimental_annotation
    • Assignment: EC-NUMBER
• Gene: Tiso_gene_18084
  • Source: orthology-esiliculosus

Pathways

• PWY-5046, 2-oxoisovalerate decarboxylation to isobutanoyl-CoA: PWY-5046
  • 3 reactions found over 3 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-esiliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-in-silico_annotation
    • Tool: pathwaytools
  • Source: annotation-experimental_annotation
    • Tool: pathwaytools

External links

• LIGAND-RXN:
  • R01701
• UNIPROT:
  • P21839
  • P21953
  • P37940
  • Q9PK54
  • P37941
  • P11178
  • P12694
  • P09061
  • P09060
  • P11960
  • O84344
  • Q9Z9E8
  • Q9I1M2
  • P35738
  • P50136
  • O48615
  • O03849
  • Q53592
  • Q53593
  • O82450