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	Ec number	Reconstruction category	Reconstruction tool	Reconstruction source	Gene associated	In pathway
1.1.1.8-RXN	EC-1.1.1.8	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 13013 Tiso gene 15777 Tiso gene 6069 Tiso gene 2810 Tiso gene 2811 Tiso gene 3718	PWY-6118 PWY-7385 PWY-7411
1.10.2.2-RXN	EC-1.10.2.2	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 7235 Tiso gene 9627 Tiso gene 4973 Tiso gene 18330 Tiso gene 15926	PWY-7279 PWY-7082 PWY-3781
1.18.1.2-RXN	EC-1.18.1.2	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 20054 Tiso gene 19031 Tiso gene 17381 Tiso gene 17170 Tiso gene 20055 Tiso gene 20168	PWY-7230 PWY-101
1.2.1.13-RXN	EC-1.2.1.13	Manual Annotation	Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation	Tiso gene 6765 Tiso gene 20000 Tiso gene 10646 Tiso gene 6766	CALVIN-PWY
1.5.1.20-RXN	EC-1.5.1.20	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 16954 Tiso gene 14582	PWY-2201 1CMET2-PWY CODH-PWY PWY-3841
1.5.5.1-RXN	EC-1.5.5.1	Orthology Manual	Pantograph	Manual-primary network Orthology-esiliculosus	Tiso gene 18526
1.8.4.9-RXN	EC-1.8.4.9	Manual		Manual-primary network		SULFMETII-PWY
1TRANSKETO-RXN	EC-2.2.1.1	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Manual-primary network Orthology-athaliana Annotation-experimental annotation Orthology-synechocystis	Tiso gene 5008 Tiso gene 11559	P124-PWY CALVIN-PWY P21-PWY PWY-5723 PWY-1861 P185-PWY NONOXIPENT-PWY
2-ISOPROPYLMALATESYN-RXN	EC-2.3.3.13	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 11453	LEUSYN-PWY PWY-6871
2.5.1.19-RXN	EC-2.5.1.19	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Manual-primary network Annotation-in-silico annotation Orthology-athaliana	Tiso gene 5752 Tiso gene 5753	PWY-6163
2.7.1.148-RXN	EC-2.7.1.148	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 13463	NONMEVIPP-PWY PWY-7560
2.7.7.60-RXN	EC-2.7.7.60	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 17568	NONMEVIPP-PWY PWY-7560
2OXOGLUTDECARB-RXN	EC-1.2.4.2	Manual Annotation	Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation	Tiso gene 10209	PWY66-398 PWY-5084
2PGADEHYDRAT-RXN	EC-4.2.1.11	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 5619 Tiso gene 13317 Tiso gene 14718 Tiso gene 8720	PWY-1042 P341-PWY PWY-2221 PWY-7124 PWY-1622 GLUCONEO-PWY GLYCOLYSIS NPGLUCAT-PWY ANAGLYCOLYSIS-PWY PWY-7218 PWY-6901 P124-PWY PWY-6886 PWY-5723 PWY-6142 P122-PWY PWY66-399 PWY-5484 PWY-7003
2TRANSKETO-RXN	EC-2.2.1.1	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Annotation-experimental annotation Orthology-athaliana Annotation-in-silico annotation Manual-primary network	Tiso gene 11559 Tiso gene 5008	PWY-6901 CALVIN-PWY P21-PWY PWY-5723 PWY-1861 P185-PWY NONOXIPENT-PWY
3-DEHYDROQUINATE-DEHYDRATASE-RXN	EC-4.2.1.10	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-athaliana Annotation-in-silico annotation Manual-primary network Orthology-esiliculosus	Tiso gene 5619 Tiso gene 14718 Tiso gene 8720 Tiso gene 5753 Tiso gene 5752	PWY-6163 PWY-6416 QUINATEDEG-PWY PWY-6707
3-DEHYDROQUINATE-SYNTHASE-RXN	EC-4.2.3.4	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 5753 Tiso gene 3446 Tiso gene 3445 Tiso gene 3974 Tiso gene 5752 Tiso gene 3447	PWY-6164
3-OXOACYL-ACP-SYNTH-BASE-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-2.3.1.41	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network	Tiso gene 19302 Tiso gene 136 Tiso gene 14485 Tiso gene 13394 Tiso gene 5939 Tiso gene 135 Tiso gene 10876 Tiso gene 500 Tiso gene 15991	PWY-5965 PWY-5966 FASYN-INITIAL-PWY PWY-7388
3PGAREARR-RXN	EC-5.4.2.12	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 16271 Tiso gene 5468 Tiso gene 14530 Tiso gene 7201 Tiso gene 20311 Tiso gene 2365 Tiso gene 10516 Tiso gene 16754 Tiso gene 9922 Tiso gene 2667 Tiso gene 15391 Tiso gene 2841 Tiso gene 15048 Tiso gene 14212 Tiso gene 9923 Tiso gene 14664	PWY-1042 P341-PWY PWY-2221 GLUCONEO-PWY GLYCOLYSIS PWY-6901 PWY-7218 P124-PWY PWY-6886 PWY-5723 PWY-6142 PWY-5484 PWY-7124 PWY-7003
4.2.1.58-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Manual Annotation	Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation	Tiso gene 6884 Tiso gene 13394 Tiso gene 136 Tiso gene 500 Tiso gene 135 Tiso gene 10876	PWY-5971 PWY-5994 PWY-7388

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