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	Ec number	Reconstruction category	Reconstruction tool	Reconstruction source	Gene associated	In pathway
1.1.1.8-RXN	EC-1.1.1.8	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 13013 Tiso gene 15777 Tiso gene 6069 Tiso gene 2810 Tiso gene 2811 Tiso gene 3718	PWY-6118 PWY-7385 PWY-7411
1.14.19.1-RXN	EC-1.14.19.1	Orthology	Pantograph	Orthology-creinhardtii Orthology-esiliculosus	Tiso gene 1497 Tiso gene 9580 Tiso gene 8027 Tiso gene 18056 Tiso gene 19322 Tiso gene 7427 Tiso gene 19215	PWY-5996
2-ISOPROPYLMALATESYN-RXN	EC-2.3.3.13	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 11453	LEUSYN-PWY PWY-6871
2.4.1.123-RXN	EC-2.4.1.123	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 18913	PWY-6524 PWY-6525 PWY-5337
2.4.1.67-RXN	EC-2.4.1.67	Orthology	Pantograph	Orthology-athaliana Orthology-creinhardtii Orthology-esiliculosus	Tiso gene 8673 Tiso gene 16101	PWY-5337
2.4.2.12-RXN	EC-2.4.2.12	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Annotation-in-silico annotation	Tiso gene 8411 Tiso gene 8186 Tiso gene 8410	NAD-BIOSYNTHESIS-III
2.5.1.19-RXN	EC-2.5.1.19	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Manual-primary network Annotation-in-silico annotation Orthology-athaliana	Tiso gene 5752 Tiso gene 5753	PWY-6163
2.7.1.121-RXN	EC-2.7.1.121	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 14441	GLYCEROLMETAB-PWY
2.7.1.148-RXN	EC-2.7.1.148	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 13463	NONMEVIPP-PWY PWY-7560
2.7.7.14-RXN	EC-2.7.7.14	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-athaliana Orthology-creinhardtii Orthology-esiliculosus	Tiso gene 18070	PWY-7782 PWY4FS-6
2.7.7.60-RXN	EC-2.7.7.60	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 17568	NONMEVIPP-PWY PWY-7560
2KETO-3METHYLVALERATE-RXN	EC-1.2.1	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 3260 Tiso gene 18084 Tiso gene 11793	PWY-5108 ILEUDEG-PWY
2PGADEHYDRAT-RXN	EC-4.2.1.11	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 5619 Tiso gene 13317 Tiso gene 14718 Tiso gene 8720	PWY-1042 P341-PWY PWY-2221 PWY-7124 PWY-1622 GLUCONEO-PWY GLYCOLYSIS NPGLUCAT-PWY ANAGLYCOLYSIS-PWY PWY-7218 PWY-6901 P124-PWY PWY-6886 PWY-5723 PWY-6142 P122-PWY PWY66-399 PWY-5484 PWY-7003
2TRANSKETO-RXN	EC-2.2.1.1	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Annotation-experimental annotation Orthology-athaliana Annotation-in-silico annotation Manual-primary network	Tiso gene 11559 Tiso gene 5008	PWY-6901 CALVIN-PWY P21-PWY PWY-5723 PWY-1861 P185-PWY NONOXIPENT-PWY
3-DEHYDROQUINATE-SYNTHASE-RXN	EC-4.2.3.4	Orthology Manual Annotation	Pantograph Pathwaytools	Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 5753 Tiso gene 3446 Tiso gene 3445 Tiso gene 3974 Tiso gene 5752 Tiso gene 3447	PWY-6164
3-DEHYDROSPHINGANINE-REDUCTASE-RXN	EC-1.1.1.102	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Annotation-in-silico annotation	Tiso gene 18518	PWY-5129 PWY3DJ-12 SPHINGOLIPID-SYN-PWY
3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN	EC-1.1.1.30	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 7191 Tiso gene 12472	PWY66-367 PWY66-368
3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN	EC-1.1.1.157	Orthology	Pantograph	Orthology-athaliana Orthology-creinhardtii Orthology-esiliculosus	Tiso gene 14026 Tiso gene 14027
3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN	EC-1.1.1.31	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Orthology-athaliana Annotation-in-silico annotation Orthology-esiliculosus Annotation-experimental annotation	Tiso gene 19590 Tiso gene 5857 Tiso gene 19771 Tiso gene 7107 Tiso gene 19772 Tiso gene 19592	VALDEG-PWY
3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN	EC-3.1.2.4	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-creinhardtii Annotation-experimental annotation	Tiso gene 2224	VALDEG-PWY

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