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	Ec number	Reconstruction category	Reconstruction tool	Reconstruction source	Gene associated	In pathway
325-BISPHOSPHATE-NUCLEOTIDASE-RXN	EC-3.1.3.7	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 12601
34HPPYRI		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 5011
35-CYCLIC-GMP-PHOSPHODIESTERASE-RXN	EC-3.1.4.35	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 9644 Tiso gene 13785 Tiso gene 12792
3PG pi thr		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 5890 Tiso gene 6426 Tiso gene 17661
3PGAREARR-RXN	EC-5.4.2.12	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 16271 Tiso gene 5468 Tiso gene 14530 Tiso gene 7201 Tiso gene 20311 Tiso gene 2365 Tiso gene 10516 Tiso gene 16754 Tiso gene 9922 Tiso gene 2667 Tiso gene 15391 Tiso gene 2841 Tiso gene 15048 Tiso gene 14212 Tiso gene 9923 Tiso gene 14664	PWY-1042 P341-PWY PWY-2221 GLUCONEO-PWY GLYCOLYSIS PWY-6901 PWY-7218 P124-PWY PWY-6886 PWY-5723 PWY-6142 PWY-5484 PWY-7124 PWY-7003
4-COUMARATE--COA-LIGASE-RXN	EC-6.2.1.12	Orthology	Pantograph	Orthology-athaliana Orthology-esiliculosus	Tiso gene 12275 Tiso gene 14183	PWY-6920 PWY-6435 PWY-7398 PWY-7046 PWY-361 PWY-7397 PWY-6320 PWY1F-FLAVSYN PWY-5754 PWY-5135 PWY-6982
4-HYDROXY-2-KETOPIMELATE-LYSIS-RXN	EC-4.1.2.52	Orthology	Pantograph	Orthology-athaliana Orthology-esiliculosus	Tiso gene 13940	3-HYDROXYPHENYLACETATE-DEGRADATION-PWY
4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN	EC-1.13.11.27	Orthology Annotation	Pantograph Pathwaytools	Orthology-athaliana Annotation-in-silico annotation Orthology-synechocystis Orthology-esiliculosus	Tiso gene 18328 Tiso gene 18976 Tiso gene 18977	PWY-1581 PWY-7432 TYRFUMCAT-PWY PWY-1422
4-NITROPHENYLPHOSPHATASE-RXN	EC-3.1.3.41	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 5996 Tiso gene 442 Tiso gene 6690 Tiso gene 18054 Tiso gene 15176 Tiso gene 6236 Tiso gene 15559 Tiso gene 18651 Tiso gene 6980 Tiso gene 15498
4.1.99.4-RXN	EC-3.5.99.7	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 11198
4.2.1.59-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation Orthology-synechocystis	Tiso gene 500 Tiso gene 13394 Tiso gene 10876 Tiso gene 135 Tiso gene 6884 Tiso gene 6885 Tiso gene 136	PWY-5971 PWY-5994
4.2.2.10-RXN	EC-4.2.2.10	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 12495 Tiso gene 1435 Tiso gene 4393 Tiso gene 13619 Tiso gene 3975 Tiso gene 3396 Tiso gene 3374 Tiso gene 3904 Tiso gene 10323
4.2.99.18-RXN	EC-4.2.99.18	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 1280 Tiso gene 5102 Tiso gene 14609 Tiso gene 6558 Tiso gene 17380
4.3.1.17-RXN	EC-4.3.1.17	Orthology Manual	Pantograph	Manual-primary network Orthology-creinhardtii Orthology-synechocystis	Tiso gene 12535
4.4.1.14-RXN	EC-4.4.1.14	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-athaliana Orthology-creinhardtii Orthology-esiliculosus	Tiso gene 8455	ETHYL-PWY PWY-7270
4OH2OXOGLUTARALDOL-RXN	EC-4.1.3.16	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 12620	HYDROXYPRODEG-PWY
5-NUCLEOTID-RXN	EC-3.1.3.5	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 6988 Tiso gene 13929 Tiso gene 14435 Tiso gene 5911 Tiso gene 6640 Tiso gene 14434 Tiso gene 14246
5-OXOPROLINASE-ATP-HYDROLYSING-RXN	EC-3.5.2.9	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Orthology-athaliana Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 3358 Tiso gene 3359	PWY-4041
5.1.1.16-RXN	EC-5.1.1.16	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 17207
5.1.1.18-RXN	EC-5.1.1.18	Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 17207	PWY-6455 PWY-6196
5.3.1.23-RXN	EC-5.3.1.23	Orthology	Pantograph	Orthology-synechocystis	Tiso gene 18341 Tiso gene 3805	PWY-7174 PWY-4361
5.3.4.1-RXN	EC-5.3.4.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 15704 Tiso gene 475 Tiso gene 4246 Tiso gene 4244 Tiso gene 7350 Tiso gene 14313
5.99.1.2-RXN	EC-5.99.1.2	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 3425 Tiso gene 1740 Tiso gene 5748 Tiso gene 5749 Tiso gene 14333 Tiso gene 200 Tiso gene 10513 Tiso gene 5035 Tiso gene 1739 Tiso gene 5036 Tiso gene 1291 Tiso gene 5747 Tiso gene 6569
5.99.1.3-RXN	EC-5.99.1.3	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 12629 Tiso gene 6569 Tiso gene 828 Tiso gene 3610 Tiso gene 3396 Tiso gene 829 Tiso gene 3728 Tiso gene 1291 Tiso gene 3374
5FLURAt		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 6578 Tiso gene 18556 Tiso gene 18433
5FTHFt		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 19115
5FTHFtm		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 19115
6-PHOSPHOFRUCTO-2-KINASE-RXN	EC-2.7.1.105	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Orthology-athaliana Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation	Tiso gene 2100 Tiso gene 892 Tiso gene 804 Tiso gene 893 Tiso gene 15398	PWY66-423
6.1.1.24-RXN	EC-6.1.1.24	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 5046 Tiso gene 5379
6.2.1.34-RXN	EC-6.2.1.34	Orthology	Pantograph	Orthology-athaliana Orthology-esiliculosus	Tiso gene 12275 Tiso gene 14183	PWY-6343 PWY-1121
6.3.2.25-RXN	EC-6.3.2.25	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 15094 Tiso gene 17234 Tiso gene 5828 Tiso gene 17450 Tiso gene 17589 Tiso gene 20330 Tiso gene 4516 Tiso gene 10591 Tiso gene 9268 Tiso gene 15093 Tiso gene 3379 Tiso gene 14575 Tiso gene 10440
6.3.4.10-RXN	EC-6.3.4.10	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 8713 Tiso gene 17216
6.3.4.11-RXN	EC-6.3.4.11	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 8713 Tiso gene 17216
6.3.4.16-RXN		Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 4685 Tiso gene 4976
6.3.4.9-RXN	EC-6.3.4.9	Orthology	Pantograph	Orthology-esiliculosus	Tiso gene 8713 Tiso gene 17216
6.3.5.6-RXN	EC-6.3.5.6	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 12219 Tiso gene 9908	PWY490-4
6MPURt		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 18556 Tiso gene 6578 Tiso gene 18433
6PFRUCTPHOS-RXN	EC-2.7.1.11	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Manual-primary network Orthology-creinhardtii	Tiso gene 5733 Tiso gene 596	PWY-1042 GLYCOLYSIS PWY-7385 PWY-1861 ANAGLYCOLYSIS-PWY PWY-5484
6PGLUCONDEHYDROG-RXN	EC-1.1.1.351	Orthology	Pantograph	Orthology-athaliana Orthology-creinhardtii Orthology-synechocystis Orthology-esiliculosus	Tiso gene 20238 Tiso gene 91 Tiso gene 7157	P122-PWY
6PGLUCONOLACT-RXN	EC-3.1.1.31	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Manual-primary network Orthology-creinhardtii	Tiso gene 10799 Tiso gene 5901 Tiso gene 15950 Tiso gene 8585 Tiso gene 20412	P122-PWY RUMP-PWY OXIDATIVEPENT-PWY GLYCOLYSIS-E-D
7KAPSYN-RXN	EC-2.3.1.47	Orthology	Pantograph	Orthology-athaliana Orthology-esiliculosus	Tiso gene 3555	PWY-6578
AAL fum		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 6720
AASP		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 17878
ABor		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 3513
ACACT		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 15327
ACACT4		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 16181
ACACT6		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 16181
ACACT7		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 16181
ACACT7m		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 16181
ACCAT		Orthology	Pantograph	Orthology-creinhardtii	Tiso gene 16181

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