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| Line 1: |
Line 1: |
| − | [[Category:Metabolite]] | + | [[Category:Pathway]] |
| − | == Metabolite [http://metacyc.org/META/NEW-IMAGE?object=CO-A CO-A] == | + | == Pathway [http://metacyc.org/META/NEW-IMAGE?object=TYRFUMCAT-PWY TYRFUMCAT-PWY] == |
| − | * smiles: | + | * taxonomic range: |
| − | ** CC(C)(C(O)C(=O)NCCC(=O)NCCS)COP(=O)(OP(=O)(OCC1(OC(C(C1OP([O-])(=O)[O-])O)N3(C2(=C(C(N)=NC=N2)N=C3))))[O-])[O-] | + | ** [http://metacyc.org/META/NEW-IMAGE?object=TAX-1224 TAX-1224] |
| − | * inchi key:
| + | ** [http://metacyc.org/META/NEW-IMAGE?object=TAX-4751 TAX-4751] |
| − | ** InChIKey=RGJOEKWQDUBAIZ-IBOSZNHHSA-J | + | ** [http://metacyc.org/META/NEW-IMAGE?object=TAX-40674 TAX-40674] |
| | * common name: | | * common name: |
| − | ** coenzyme A | + | ** L-tyrosine degradation I |
| − | * molecular weight:
| + | |
| − | ** 763.502
| + | |
| | * Synonym(s): | | * Synonym(s): |
| − | ** CoA | + | ** tyrosine fumarate catabolism |
| − | ** co-A-SH
| + | |
| − | ** co-enzyme-A
| + | |
| − | ** co-A
| + | |
| − | ** HS-CoA
| + | |
| | | | |
| − | == Reaction(s) known to consume the compound == | + | == Reaction(s) found == |
| − | * [[RXN66-483]]
| + | '''5''' reactions found over '''5''' reactions in the full pathway |
| − | * [[RXN66-480]] | + | * [[4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN]] |
| − | * [[RXN-16402]]
| + | ** 1 associated gene(s): |
| − | * [[RXN66-469]]
| + | *** [[CHC_T00009321001_1]] |
| − | * [[RXN66-484]]
| + | ** 3 reconstruction source(s) associated: |
| − | * [[RXN-17116]]
| + | *** [[orthology-arabidopsis_thaliana]] |
| − | * [[RXN-1126]] | + | *** [[orthology-ectocarpus_siliculosus]] |
| − | * [[RXN0-7248]] | + | *** [[orthology-galdieria.sulphuraria]] |
| − | * [[LINOLENOYL-RXN]] | + | * [[FUMARYLACETOACETASE-RXN]] |
| − | * [[RXN-14268]] | + | ** 2 associated gene(s): |
| − | * [[RXN-2001]] | + | *** [[CHC_T00010274001]] |
| − | * [[RXN-16389]] | + | *** [[CHC_T00005558001_1]] |
| − | * [[ACYLCOASYN-RXN]] | + | ** 3 reconstruction source(s) associated: |
| − | * [[RXN-17791]] | + | *** [[annotation-original_genome]] |
| − | * [[RXN-16380]] | + | *** [[orthology-arabidopsis_thaliana]] |
| − | * [[RXN-17799]] | + | *** [[orthology-galdieria.sulphuraria]] |
| − | * [[RXN-10919]] | + | * [[HOMOGENTISATE-12-DIOXYGENASE-RXN]] |
| − | * [[RXN-13617]] | + | ** 2 associated gene(s): |
| − | * [[ACETATE--COA-LIGASE-RXN]] | + | *** [[CHC_T00008952001_1]] |
| − | * [[RXN-9673]] | + | *** [[CHC_T00008952001]] |
| − | * [[ACETOACETATE--COA-LIGASE-RXN]] | + | ** 3 reconstruction source(s) associated: |
| − | * [[RXN-16401]] | + | *** [[annotation-original_genome]] |
| − | * [[PYRUVDEH-RXN]] | + | *** [[orthology-ectocarpus_siliculosus]] |
| − | * [[ATP-CITRATE-PRO-S--LYASE-RXN]] | + | *** [[orthology-galdieria.sulphuraria]] |
| − | * [[RXN-17795]] | + | * [[MALEYLACETOACETATE-ISOMERASE-RXN]] |
| − | * [[RXN-13614]] | + | ** 1 associated gene(s): |
| − | * [[RXN-16137]] | + | *** [[CHC_T00008425001_1]] |
| − | * [[2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN]] | + | ** 1 reconstruction source(s) associated: |
| − | * [[RXN-12710]] | + | *** [[orthology-galdieria.sulphuraria]] |
| − | * [[2OXOGLUTARATEDEH-RXN]] | + | * [[TYROSINE-AMINOTRANSFERASE-RXN]] |
| − | * [[RXN-17778]] | + | ** 2 associated gene(s): |
| − | * [[RXN-7904]] | + | *** [[CHC_T00008863001_1]] |
| − | * [[RXN66-474]] | + | *** [[CHC_T00008863001]] |
| − | * [[RXN-14793]] | + | ** 2 reconstruction source(s) associated: |
| − | * [[RXN-16418]] | + | *** [[annotation-original_genome]] |
| − | * [[RXN-12978]] | + | *** [[orthology-galdieria.sulphuraria]] |
| − | * [[RXN66-477]] | + | == Reaction(s) not found == |
| − | * [[RXN-14799]] | + | |
| − | * [[RXN-10699]] | + | |
| − | * [[RXN-12184]] | + | |
| − | * [[RXN-14774]] | + | |
| − | * [[RXN-17787]] | + | |
| − | * [[RXN-13290]]
| + | |
| − | * [[RXN0-7239]]
| + | |
| − | * [[RXN-17782]]
| + | |
| − | * [[RXN-14803]]
| + | |
| − | * [[RXN-16393]]
| + | |
| − | * [[RXN-14394]]
| + | |
| − | * [[R223-RXN]]
| + | |
| − | * [[TRANS-RXN0-623]]
| + | |
| − | * [[RXN-10700]]
| + | |
| − | * [[RXN-10701]]
| + | |
| − | * [[RXN-9644]]
| + | |
| − | * [[1.2.1.25-RXN]]
| + | |
| − | * [[RXN0-7238]] | + | |
| − | * [[RXN66-474-R-2-HYDROXYSTEARATE/ATP/CO-A//CPD-14717/AMP/PPI.48.]]
| + | |
| − | * [[RXN-14788]]
| + | |
| − | * [[6.2.1.34-RXN]] | + | |
| − | * [[2-KETO-ADIPATE-DEHYDROG-RXN]] | + | |
| − | * [[RXN-9623]]
| + | |
| − | * [[KETOACYLCOATHIOL-RXN]]
| + | |
| − | * [[4-COUMARATE--COA-LIGASE-RXN]]
| + | |
| − | * [[RXN-11246]]
| + | |
| − | * [[ExchangeDeadEnd_CO-A]]
| + | |
| − | == Reaction(s) known to produce the compound ==
| + | |
| − | * [[RXN-16562]] | + | |
| − | * [[RXN-17010]] | + | |
| − | * [[RXN-7645]] | + | |
| − | * [[NARINGENIN-CHALCONE-SYNTHASE-RXN]] | + | |
| − | * [[RXN-11468]] | + | |
| − | * [[7KAPSYN-RXN]] | + | |
| − | * [[RXN-16118]] | + | |
| − | * [[MALONYL-COA-ACP-TRANSACYL-RXN]] | + | |
| − | * [[RXN-17744]]
| + | |
| − | * [[RXN-9652]]
| + | |
| − | * [[RXN-1106]]
| + | |
| − | * [[RXN-9651]]
| + | |
| − | * [[RXN-1101]]
| + | |
| − | * [[SERINE-C-PALMITOYLTRANSFERASE-RXN]]
| + | |
| − | * [[RXN-9654]]
| + | |
| − | * [[RXN-9653]]
| + | |
| − | * [[RXN-9650]]
| + | |
| − | * [[SERINE-O-ACETTRAN-RXN]]
| + | |
| − | * [[3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN]]
| + | |
| − | * [[RXN-9626]] | + | |
| − | * [[RXN0-1133]] | + | |
| − | * [[RXN-16016]] | + | |
| − | * [[RXN-13322]] | + | |
| − | * [[RXN-12565]] | + | |
| − | * [[RXN-17860]] | + | |
| − | * [[RXN-17861]] | + | |
| − | * [[RXN-17862]] | + | |
| − | * [[RXN-17863]] | + | |
| − | * [[RXN-17019]] | + | |
| − | * [[RXN-9632]]
| + | |
| − | * [[RXN-17743]]
| + | |
| − | * [[2-ISOPROPYLMALATESYN-RXN]] | + | |
| − | * [[RXN1G-368]] | + | |
| − | * [[DEPHOSPHOCOAKIN-RXN]] | + | |
| − | * [[RXN-17021]] | + | |
| − | * [[RXN-17729]] | + | |
| − | * [[RXN-17023]] | + | |
| − | * [[RXN-17008]] | + | |
| − | * [[RXN-17850]] | + | |
| − | * [[DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN]] | + | |
| − | * [[RXN1G-499]] | + | |
| − | * [[RXN-17011]]
| + | |
| − | * [[RXN1G-445]]
| + | |
| − | * [[DIHYDLIPACETRANS-RXN]]
| + | |
| − | * [[THIOESTER-RXN[CCO-CYTOSOL]-CPD-10280/WATER//TETRACOSANOATE/CO-A/PROTON.57.]]
| + | |
| − | * [[FATTY-ACYL-COA-SYNTHASE-RXN]] | + | |
| − | * [[RXN-10059]] | + | |
| − | * [[5-AMINOLEVULINIC-ACID-SYNTHASE-RXN]] | + | |
| − | * [[RXN-17009]] | + | |
| − | * [[BIOMASS-RXN]] | + | |
| − | * [[RXN-17864]] | + | |
| − | * [[RXN-16032]] | + | |
| − | * [[RXN-13297]] | + | |
| − | * [[RXN-12568-HEXANAL/CO-A/NADP//HEXANOYL-COA/NADPH/PROTON.45.]] | + | |
| − | * [[RXN-13295]] | + | |
| − | * [[CITSYN-RXN]] | + | |
| − | * [[RXN-16117]] | + | |
| − | * [[RXN-17853]] | + | |
| − | * [[RXN-1381]] | + | |
| − | * [[RXN-3142]] | + | |
| − | * [[RXN-15044]] | + | |
| − | * [[RXN-15045]] | + | |
| − | * [[RXN-9728]]
| + | |
| − | * [[RXN-9648]]
| + | |
| − | * [[RXN-9344-CPD-10279/NADPH/PROTON//CPD-7845/CO-A/NADP.43.]]
| + | |
| − | * [[RXN-15043]]
| + | |
| − | * [[RXN-6384]]
| + | |
| − | * [[RXN0-6948]]
| + | |
| − | * [[GLUCOSAMINEPNACETYLTRANS-RXN]]
| + | |
| − | * [[RXN-1623]]
| + | |
| − | * [[RXN-17855]]
| + | |
| − | * [[RXN-17854]]
| + | |
| − | * [[RXN-17857]]
| + | |
| − | * [[RXN-17856]]
| + | |
| − | * [[RXN-17851]]
| + | |
| − | * [[HOMSUCTRAN-RXN]]
| + | |
| − | * [[RXN-13721]]
| + | |
| − | * [[RXN-17852]]
| + | |
| − | * [[RXN-9629]]
| + | |
| − | * [[RXN-17859]]
| + | |
| − | * [[RXN-17858]]
| + | |
| − | * [[RXN-12568-HEXANAL/CO-A/NAD//HEXANOYL-COA/NADH/PROTON.43.]]
| + | |
| − | * [[ExchangeDeadEnd_CO-A]]
| + | |
| − | == Reaction(s) of unknown directionality == | + | |
| − | * [[PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN]]
| + | |
| − | * [[RXN-13805]]
| + | |
| − | * [[RXN1G-460]]
| + | |
| − | * [[RXN-1124]]
| + | |
| − | * [[RXN-16066]]
| + | |
| − | * [[HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN]]
| + | |
| − | * [[2.3.1.97-RXN]]
| + | |
| − | * [[1.1.1.34-RXN]]
| + | |
| − | * [[FATTY-ACID-SYNTHASE-RXN]]
| + | |
| − | * [[HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN]]
| + | |
| − | * [[RXN-16415-TETRACOSANOATE/ATP/CO-A//CPD-10280/AMP/PPI.43.]]
| + | |
| − | * [[RXN-12561]]
| + | |
| − | * [[RXN-15036]]
| + | |
| − | * [[METHYLACETOACETYLCOATHIOL-RXN]]
| + | |
| − | * [[HISTONE-ACETYLTRANSFERASE-RXN]]
| + | |
| − | * [[RXN-14274]]
| + | |
| − | * [[RXN-14277]]
| + | |
| − | * [[BUTANAL-DEHYDROGENASE-RXN-BUTANAL/CO-A/NADP//BUTYRYL-COA/NADPH/PROTON.44.]]
| + | |
| − | * [[RXN0-1147]]
| + | |
| − | * [[RXN-7825]]
| + | |
| − | * [[ACETYL-COA-ACETYLTRANSFER-RXN]]
| + | |
| − | * [[SUCCCOASYN-RXN]]
| + | |
| − | * [[2.3.1.168-RXN]]
| + | |
| − | * [[2KETO-3METHYLVALERATE-RXN]]
| + | |
| − | * [[N-ACETYLTRANSFER-RXN]]
| + | |
| − | * [[RXN3O-8214]]
| + | |
| − | * [[ACP-S-ACETYLTRANSFER-RXN]]
| + | |
| − | * [[BUTANAL-DEHYDROGENASE-RXN-BUTANAL/CO-A/NAD//BUTYRYL-COA/NADH/PROTON.42.]]
| + | |
| − | * [[RXN-16415]]
| + | |
| − | * [[ACETALD-DEHYDROG-RXN]]
| + | |
| | == External links == | | == External links == |
| − | * CAS : 85-61-0 | + | * UM-BBD-PWY : tyr |
| − | * Wikipedia : Coenzyme_a
| + | {{#set: taxonomic range=TAX-1224}} |
| − | * METABOLIGHTS : MTBLC57287
| + | {{#set: taxonomic range=TAX-4751}} |
| − | * PUBCHEM:
| + | {{#set: taxonomic range=TAX-40674}} |
| − | ** [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=25113190 25113190]
| + | {{#set: common name=L-tyrosine degradation I}} |
| − | * KNAPSACK : C00007258
| + | {{#set: common name=tyrosine fumarate catabolism}} |
| − | * HMDB : HMDB01423
| + | {{#set: reaction found=5}} |
| − | * LIGAND-CPD:
| + | {{#set: total reaction=5}} |
| − | ** [http://www.genome.jp/dbget-bin/www_bget?C00010 C00010]
| + | {{#set: completion rate=100.0}} |
| − | * CHEBI:
| + | |
| − | ** [http://www.ebi.ac.uk/chebi/searchId.do?chebiId=57287 57287]
| + | |
| − | * BIGG : coa
| + | |
| − | {{#set: smiles=CC(C)(C(O)C(=O)NCCC(=O)NCCS)COP(=O)(OP(=O)(OCC1(OC(C(C1OP([O-])(=O)[O-])O)N3(C2(=C(C(N)=NC=N2)N=C3))))[O-])[O-]}} | + | |
| − | {{#set: inchi key=InChIKey=RGJOEKWQDUBAIZ-IBOSZNHHSA-J}} | + | |
| − | {{#set: common name=coenzyme A}} | + | |
| − | {{#set: molecular weight=763.502 }} | + | |
| − | {{#set: common name=CoA|co-A-SH|co-enzyme-A|co-A|HS-CoA}} | + | |
| − | {{#set: consumed by=RXN66-483|RXN66-480|RXN-16402|RXN66-469|RXN66-484|RXN-17116|RXN-1126|RXN0-7248|LINOLENOYL-RXN|RXN-14268|RXN-2001|RXN-16389|ACYLCOASYN-RXN|RXN-17791|RXN-16380|RXN-17799|RXN-10919|RXN-13617|ACETATE--COA-LIGASE-RXN|RXN-9673|ACETOACETATE--COA-LIGASE-RXN|RXN-16401|PYRUVDEH-RXN|ATP-CITRATE-PRO-S--LYASE-RXN|RXN-17795|RXN-13614|RXN-16137|2KETO-4METHYL-PENTANOATE-DEHYDROG-RXN|RXN-12710|2OXOGLUTARATEDEH-RXN|RXN-17778|RXN-7904|RXN66-474|RXN-14793|RXN-16418|RXN-12978|RXN66-477|RXN-14799|RXN-10699|RXN-12184|RXN-14774|RXN-17787|RXN-13290|RXN0-7239|RXN-17782|RXN-14803|RXN-16393|RXN-14394|R223-RXN|TRANS-RXN0-623|RXN-10700|RXN-10701|RXN-9644|1.2.1.25-RXN|RXN0-7238|RXN66-474-R-2-HYDROXYSTEARATE/ATP/CO-A//CPD-14717/AMP/PPI.48.|RXN-14788|6.2.1.34-RXN|2-KETO-ADIPATE-DEHYDROG-RXN|RXN-9623|KETOACYLCOATHIOL-RXN|4-COUMARATE--COA-LIGASE-RXN|RXN-11246|ExchangeDeadEnd_CO-A}} | + | |
| − | {{#set: produced by=RXN-16562|RXN-17010|RXN-7645|NARINGENIN-CHALCONE-SYNTHASE-RXN|RXN-11468|7KAPSYN-RXN|RXN-16118|MALONYL-COA-ACP-TRANSACYL-RXN|RXN-17744|RXN-9652|RXN-1106|RXN-9651|RXN-1101|SERINE-C-PALMITOYLTRANSFERASE-RXN|RXN-9654|RXN-9653|RXN-9650|SERINE-O-ACETTRAN-RXN|3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN|RXN-9626|RXN0-1133|RXN-16016|RXN-13322|RXN-12565|RXN-17860|RXN-17861|RXN-17862|RXN-17863|RXN-17019|RXN-9632|RXN-17743|2-ISOPROPYLMALATESYN-RXN|RXN1G-368|DEPHOSPHOCOAKIN-RXN|RXN-17021|RXN-17729|RXN-17023|RXN-17008|RXN-17850|DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN|RXN1G-499|RXN-17011|RXN1G-445|DIHYDLIPACETRANS-RXN|THIOESTER-RXN[CCO-CYTOSOL]-CPD-10280/WATER//TETRACOSANOATE/CO-A/PROTON.57.|FATTY-ACYL-COA-SYNTHASE-RXN|RXN-10059|5-AMINOLEVULINIC-ACID-SYNTHASE-RXN|RXN-17009|BIOMASS-RXN|RXN-17864|RXN-16032|RXN-13297|RXN-12568-HEXANAL/CO-A/NADP//HEXANOYL-COA/NADPH/PROTON.45.|RXN-13295|CITSYN-RXN|RXN-16117|RXN-17853|RXN-1381|RXN-3142|RXN-15044|RXN-15045|RXN-9728|RXN-9648|RXN-9344-CPD-10279/NADPH/PROTON//CPD-7845/CO-A/NADP.43.|RXN-15043|RXN-6384|RXN0-6948|GLUCOSAMINEPNACETYLTRANS-RXN|RXN-1623|RXN-17855|RXN-17854|RXN-17857|RXN-17856|RXN-17851|HOMSUCTRAN-RXN|RXN-13721|RXN-17852|RXN-9629|RXN-17859|RXN-17858|RXN-12568-HEXANAL/CO-A/NAD//HEXANOYL-COA/NADH/PROTON.43.|ExchangeDeadEnd_CO-A}} | + | |
| − | {{#set: consumed or produced by=PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN|RXN-13805|RXN1G-460|RXN-1124|RXN-16066|HYDROXYMETHYLGLUTARYL-COA-REDUCTASE-RXN|2.3.1.97-RXN|1.1.1.34-RXN|FATTY-ACID-SYNTHASE-RXN|HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN|RXN-16415-TETRACOSANOATE/ATP/CO-A//CPD-10280/AMP/PPI.43.|RXN-12561|RXN-15036|METHYLACETOACETYLCOATHIOL-RXN|HISTONE-ACETYLTRANSFERASE-RXN|RXN-14274|RXN-14277|BUTANAL-DEHYDROGENASE-RXN-BUTANAL/CO-A/NADP//BUTYRYL-COA/NADPH/PROTON.44.|RXN0-1147|RXN-7825|ACETYL-COA-ACETYLTRANSFER-RXN|SUCCCOASYN-RXN|2.3.1.168-RXN|2KETO-3METHYLVALERATE-RXN|N-ACETYLTRANSFER-RXN|RXN3O-8214|ACP-S-ACETYLTRANSFER-RXN|BUTANAL-DEHYDROGENASE-RXN-BUTANAL/CO-A/NAD//BUTYRYL-COA/NADH/PROTON.42.|RXN-16415|ACETALD-DEHYDROG-RXN}} | + | |
