HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN

Reaction HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN

• direction:
  • LEFT-TO-RIGHT
• ec number:
  • EC-4.1.3.4
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 3-HYDROXY-3-METHYL-GLUTARYL-COA[c] => 1 ACETYL-COA[c] + 1 3-KETOBUTYRATE[c]
• With common name(s):
  • 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] => 1 acetyl-CoA[c] + 1 acetoacetate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: CHC_T00004158001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus
  • Source: orthology-arabidopsis_thaliana

Pathways

• PWY66-367, ketogenesis: PWY66-367
  • 4 reactions found over 5 reactions in the full pathway
• LEU-DEG2-PWY, L-leucine degradation I: LEU-DEG2-PWY
  • 3 reactions found over 6 reactions in the full pathway
• PWY-5074, mevalonate degradation: PWY-5074
  • 1 reactions found over 2 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-galdieria.sulphuraria
    • Tool: pantograph
  • Source: orthology-arabidopsis_thaliana
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph

External links

• RHEA:
  • 24404
• UNIPROT:
  • P35914
  • P35915
  • Q8L7K2
• LIGAND-RXN:
  • R01360