HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN

Reaction HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN

• direction:
  • REVERSIBLE
• common name:
  • Thiolase-like, subgroup
  • Hydroxymethylglutaryl-CoA synthase
• ec number:
  • EC-2.3.3.10
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 ACETYL-COA[c] + 1 ACETOACETYL-COA[c] + 1 WATER[c] <=> 1 3-HYDROXY-3-METHYL-GLUTARYL-COA[c] + 1 CO-A[c] + 1 PROTON[c]
• With common name(s):
  • 1 acetyl-CoA[c] + 1 acetoacetyl-CoA[c] + 1 H2O[c] <=> 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] + 1 coenzyme A[c] + 1 H+[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: Ec-19_002030
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
• Gene: Ec-21_004360
  • Source: annotation-esiliculosus_genome
    • Assignment: EC-NUMBER
  • Source: orthology-aragem

Pathways

• PWY66-367, ketogenesis: PWY66-367
  • 3 reactions found over 5 reactions in the full pathway
• PWY-6174, mevalonate pathway II (archaea): PWY-6174
  • 5 reactions found over 7 reactions in the full pathway
• PWY-922, mevalonate pathway I: PWY-922
  • 7 reactions found over 7 reactions in the full pathway
• PWY-7391, isoprene biosynthesis II (engineered): PWY-7391
  • 7 reactions found over 8 reactions in the full pathway
• PWY-7571, ferrichrome A biosynthesis: PWY-7571
  • 2 reactions found over 5 reactions in the full pathway
• PWY-7524, mevalonate pathway III (archaea): PWY-7524
  • 4 reactions found over 8 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-aragem
    • Tool: pantograph
• Category: annotation
  • Source: annotation-esiliculosus_genome
    • Tool: pathwaytools

External links

• RHEA:
  • 10188
• LIGAND-RXN:
  • R01978
• UNIPROT:
  • P13704
  • P22791
  • P54870
  • P54869
  • O51626
  • Q9CFA9
  • P17425
  • Q7LZE7
  • Q01581
  • P54961
  • P54839
  • P54874
  • P54868
  • P54873
  • P93773