Difference between revisions of "1.1.1.34-RXN"

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(Created page with "Category:Metabolite == Metabolite [http://metacyc.org/META/NEW-IMAGE?object=CPD-18492 CPD-18492] == * smiles: ** CCCCCC=CCC=CCC=CCC=CCC=CCCC=CC(SCCNC(=O)CCNC(=O)C(O)C(C)(C...")
 
(Created page with "Category:Reaction == Reaction [http://metacyc.org/META/NEW-IMAGE?object=1.1.1.34-RXN 1.1.1.34-RXN] == * direction: ** REVERSIBLE * common name: ** hydroxymethylglutaryl-Co...")
 
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[[Category:Metabolite]]
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[[Category:Reaction]]
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== Metabolite [http://metacyc.org/META/NEW-IMAGE?object=CPD-18492 CPD-18492] ==
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== Reaction [http://metacyc.org/META/NEW-IMAGE?object=1.1.1.34-RXN 1.1.1.34-RXN] ==
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* smiles:
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* direction:
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** CCCCCC=CCC=CCC=CCC=CCC=CCCC=CC(SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(OP(=O)(OCC1(C(OP([O-])(=O)[O-])C(O)C(O1)N3(C2(=C(C(N)=NC=N2)N=C3))))[O-])[O-])=O
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** REVERSIBLE
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* inchi key:
+
−
** InChIKey=UYOKHWFEUAJFMG-UIYHDVLFSA-J
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* common name:
 
* common name:
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** (2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA
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** hydroxymethylglutaryl-CoA reductase (NADPH)
−
* molecular weight:
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** Hydroxymethylglutaryl-CoA reductase, class I/II
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** 1102.034   
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** Hydroxymethylglutaryl-CoA reductase, N-terminal
 +
* ec number:
 +
** [http://enzyme.expasy.org/EC/1.1.1.34 EC-1.1.1.34]
 
* Synonym(s):
 
* Synonym(s):
−
** (2E,6Z,9Z,12Z,15Z,18Z)-tetracosa-2,6,9,12,15,18-hexaenoyl-CoA
 
  
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== Reaction(s) known to consume the compound ==
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== Reaction Formula ==
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* [[RXN-17114]]
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* With identifiers:
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== Reaction(s) known to produce the compound ==
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** 1 [[MEVALONATE]][c] '''+''' 2 [[NADP]][c] '''+''' 1 [[CO-A]][c] '''<=>''' 2 [[PROTON]][c] '''+''' 1 [[3-HYDROXY-3-METHYL-GLUTARYL-COA]][c] '''+''' 2 [[NADPH]][c]
−
* [[RXN-17113]]
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* With common name(s):
−
== Reaction(s) of unknown directionality ==
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** 1 (R)-mevalonate[c] '''+''' 2 NADP+[c] '''+''' 1 coenzyme A[c] '''<=>''' 2 H+[c] '''+''' 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] '''+''' 2 NADPH[c]
 +
 
 +
== Genes associated with this reaction  ==
 +
Genes have been associated with this reaction based on different elements listed below.
 +
* Gene: [[Ec-03_000570]]
 +
** Source: [[annotation-esiliculosus_genome]]
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*** Assignment: EC-NUMBER
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** Source: [[orthology-aragem]]
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* Gene: [[Ec-03_000580]]
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** Source: [[annotation-esiliculosus_genome]]
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*** Assignment: EC-NUMBER
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* Gene: [[Ec-08_002990]]
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** Source: [[annotation-esiliculosus_genome]]
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*** Assignment: EC-NUMBER
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** Source: [[orthology-aragem]]
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* Gene: [[Ec-27_005710]]
 +
** Source: [[annotation-esiliculosus_genome]]
 +
*** Assignment: GO-TERM
 +
== Pathways  ==
 +
* [[PWY-922]], mevalonate pathway I: [http://metacyc.org/META/NEW-IMAGE?object=PWY-922 PWY-922]
 +
** '''7''' reactions found over '''7''' reactions in the full pathway
 +
* [[PWY-6174]], mevalonate pathway II (archaea): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6174 PWY-6174]
 +
** '''5''' reactions found over '''7''' reactions in the full pathway
 +
* [[PWY-7391]], isoprene biosynthesis II (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7391 PWY-7391]
 +
** '''7''' reactions found over '''8''' reactions in the full pathway
 +
* [[PWY-7524]], mevalonate pathway III (archaea): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7524 PWY-7524]
 +
** '''4''' reactions found over '''8''' reactions in the full pathway
 +
== Reconstruction information  ==
 +
* Category: [[orthology]]
 +
** Source: [[orthology-aragem]]
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*** Tool: [[pantograph]]
 +
* Category: [[annotation]]
 +
** Source: [[annotation-esiliculosus_genome]]
 +
*** Tool: [[pathwaytools]]
 
== External links  ==
 
== External links  ==
−
{{#set: smiles=CCCCCC=CCC=CCC=CCC=CCC=CCCC=CC(SCCNC(=O)CCNC(=O)C(O)C(C)(C)COP(=O)(OP(=O)(OCC1(C(OP([O-])(=O)[O-])C(O)C(O1)N3(C2(=C(C(N)=NC=N2)N=C3))))[O-])[O-])=O}}
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* RHEA:
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{{#set: inchi key=InChIKey=UYOKHWFEUAJFMG-UIYHDVLFSA-J}}
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** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=15989 15989]
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{{#set: common name=(2E,6Z,9Z,12Z,15Z,18Z)-tetracosahexaenoyl-CoA}}
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* LIGAND-RXN:
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{{#set: molecular weight=1102.034    }}
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** [http://www.genome.jp/dbget-bin/www_bget?R02082 R02082]
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{{#set: common name=(2E,6Z,9Z,12Z,15Z,18Z)-tetracosa-2,6,9,12,15,18-hexaenoyl-CoA}}
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* UNIPROT:
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{{#set: consumed by=RXN-17114}}
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** [http://www.uniprot.org/uniprot/P16393 P16393]
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{{#set: produced by=RXN-17113}}
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** [http://www.uniprot.org/uniprot/P14891 P14891]
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** [http://www.uniprot.org/uniprot/P16237 P16237]
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** [http://www.uniprot.org/uniprot/P20715 P20715]
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** [http://www.uniprot.org/uniprot/Q59468 Q59468]
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** [http://www.uniprot.org/uniprot/Q01237 Q01237]
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** [http://www.uniprot.org/uniprot/Q61671 Q61671]
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** [http://www.uniprot.org/uniprot/Q944T9 Q944T9]
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** [http://www.uniprot.org/uniprot/Q9S9C2 Q9S9C2]
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** [http://www.uniprot.org/uniprot/Q9S999 Q9S999]
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** [http://www.uniprot.org/uniprot/Q9S998 Q9S998]
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** [http://www.uniprot.org/uniprot/Q9S997 Q9S997]
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** [http://www.uniprot.org/uniprot/P04035 P04035]
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** [http://www.uniprot.org/uniprot/P00347 P00347]
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** [http://www.uniprot.org/uniprot/P29058 P29058]
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** [http://www.uniprot.org/uniprot/P29057 P29057]
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** [http://www.uniprot.org/uniprot/Q12577 Q12577]
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** [http://www.uniprot.org/uniprot/Q12649 Q12649]
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** [http://www.uniprot.org/uniprot/Q00583 Q00583]
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** [http://www.uniprot.org/uniprot/Q01559 Q01559]
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** [http://www.uniprot.org/uniprot/P48022 P48022]
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** [http://www.uniprot.org/uniprot/Q43825 Q43825]
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** [http://www.uniprot.org/uniprot/Q43826 Q43826]
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** [http://www.uniprot.org/uniprot/P14773 P14773]
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** [http://www.uniprot.org/uniprot/Q7M4W2 Q7M4W2]
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** [http://www.uniprot.org/uniprot/Q7M4W1 Q7M4W1]
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** [http://www.uniprot.org/uniprot/Q7M4W4 Q7M4W4]
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** [http://www.uniprot.org/uniprot/Q7M4W3 Q7M4W3]
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** [http://www.uniprot.org/uniprot/P48019 P48019]
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** [http://www.uniprot.org/uniprot/Q41454 Q41454]
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** [http://www.uniprot.org/uniprot/Q42506 Q42506]
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** [http://www.uniprot.org/uniprot/Q41455 Q41455]
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** [http://www.uniprot.org/uniprot/Q41456 Q41456]
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** [http://www.uniprot.org/uniprot/Q41458 Q41458]
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** [http://www.uniprot.org/uniprot/P48020 P48020]
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** [http://www.uniprot.org/uniprot/Q9FS01 Q9FS01]
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** [http://www.uniprot.org/uniprot/Q42466 Q42466]
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** [http://www.uniprot.org/uniprot/O48624 O48624]
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** [http://www.uniprot.org/uniprot/O04188 O04188]
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** [http://www.uniprot.org/uniprot/O24594 O24594]
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** [http://www.uniprot.org/uniprot/Q41438 Q41438]
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** [http://www.uniprot.org/uniprot/O64966 O64966]
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** [http://www.uniprot.org/uniprot/O64967 O64967]
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** [http://www.uniprot.org/uniprot/Q03163 Q03163]
 +
** [http://www.uniprot.org/uniprot/Q39628 Q39628]
 +
** [http://www.uniprot.org/uniprot/P93514 P93514]
 +
** [http://www.uniprot.org/uniprot/O08424 O08424]
 +
{{#set: direction=REVERSIBLE}}
 +
{{#set: common name=hydroxymethylglutaryl-CoA reductase (NADPH)}}
 +
{{#set: common name=Hydroxymethylglutaryl-CoA reductase, class I/II}}
 +
{{#set: common name=Hydroxymethylglutaryl-CoA reductase, N-terminal}}
 +
{{#set: ec number=EC-1.1.1.34}}
 +
{{#set: gene associated=Ec-03_000570|Ec-03_000580|Ec-08_002990|Ec-27_005710}}
 +
{{#set: in pathway=PWY-922|PWY-6174|PWY-7391|PWY-7524}}
 +
{{#set: reconstruction category=orthology|annotation}}
 +
{{#set: reconstruction source=annotation-esiliculosus_genome|orthology-aragem}}
 +
{{#set: reconstruction tool=pantograph|pathwaytools}}

Latest revision as of 19:31, 21 March 2018

Reaction 1.1.1.34-RXN

  • direction:
    • REVERSIBLE
  • common name:
    • hydroxymethylglutaryl-CoA reductase (NADPH)
    • Hydroxymethylglutaryl-CoA reductase, class I/II
    • Hydroxymethylglutaryl-CoA reductase, N-terminal
  • ec number:
  • Synonym(s):

Reaction Formula

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

Pathways

  • PWY-922, mevalonate pathway I: PWY-922
    • 7 reactions found over 7 reactions in the full pathway
  • PWY-6174, mevalonate pathway II (archaea): PWY-6174
    • 5 reactions found over 7 reactions in the full pathway
  • PWY-7391, isoprene biosynthesis II (engineered): PWY-7391
    • 7 reactions found over 8 reactions in the full pathway
  • PWY-7524, mevalonate pathway III (archaea): PWY-7524
    • 4 reactions found over 8 reactions in the full pathway

Reconstruction information

External links






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