Difference between revisions of "1.1.1.34-RXN"

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(Created page with "Category:Metabolite == Metabolite [http://metacyc.org/META/NEW-IMAGE?object=ITACONATE ITACONATE] == * smiles: ** C=C(C(=O)[O-])CC([O-])=O * inchi key: ** InChIKey=LVHBHZAN...")
(Created page with "Category:Reaction == Reaction [http://metacyc.org/META/NEW-IMAGE?object=1.1.1.34-RXN 1.1.1.34-RXN] == * direction: ** REVERSIBLE * common name: ** hydroxymethylglutaryl-Co...")
 
(One intermediate revision by the same user not shown)
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[[Category:Metabolite]]
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[[Category:Reaction]]
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== Metabolite [http://metacyc.org/META/NEW-IMAGE?object=ITACONATE ITACONATE] ==
+
== Reaction [http://metacyc.org/META/NEW-IMAGE?object=1.1.1.34-RXN 1.1.1.34-RXN] ==
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* smiles:
+
* direction:
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** C=C(C(=O)[O-])CC([O-])=O
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** REVERSIBLE
−
* inchi key:
+
−
** InChIKey=LVHBHZANLOWSRM-UHFFFAOYSA-L
+
 
* common name:
 
* common name:
−
** itaconate
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** hydroxymethylglutaryl-CoA reductase (NADPH)
−
* molecular weight:
+
** Hydroxymethylglutaryl-CoA reductase, class I/II
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** 128.084   
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** Hydroxymethylglutaryl-CoA reductase, N-terminal
 +
* ec number:
 +
** [http://enzyme.expasy.org/EC/1.1.1.34 EC-1.1.1.34]
 
* Synonym(s):
 
* Synonym(s):
−
** propylenedicarboxylic acid
 
−
** methylenebutanedioic acid
 
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** 2-propene-1,2-dicarboxylic acid
 
−
** methylenesuccinic acid
 
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** itaconic acid
 
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** 2-methylsuccinate
 
  
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== Reaction(s) known to consume the compound ==
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== Reaction Formula ==
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* [[RXN-8988]]
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* With identifiers:
−
== Reaction(s) known to produce the compound ==
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** 1 [[MEVALONATE]][c] '''+''' 2 [[NADP]][c] '''+''' 1 [[CO-A]][c] '''<=>''' 2 [[PROTON]][c] '''+''' 1 [[3-HYDROXY-3-METHYL-GLUTARYL-COA]][c] '''+''' 2 [[NADPH]][c]
−
== Reaction(s) of unknown directionality ==
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* With common name(s):
 +
** 1 (R)-mevalonate[c] '''+''' 2 NADP+[c] '''+''' 1 coenzyme A[c] '''<=>''' 2 H+[c] '''+''' 1 (S)-3-hydroxy-3-methylglutaryl-CoA[c] '''+''' 2 NADPH[c]
 +
 
 +
== Genes associated with this reaction  ==
 +
Genes have been associated with this reaction based on different elements listed below.
 +
* Gene: [[Ec-03_000570]]
 +
** Source: [[annotation-esiliculosus_genome]]
 +
*** Assignment: EC-NUMBER
 +
** Source: [[orthology-aragem]]
 +
* Gene: [[Ec-03_000580]]
 +
** Source: [[annotation-esiliculosus_genome]]
 +
*** Assignment: EC-NUMBER
 +
* Gene: [[Ec-08_002990]]
 +
** Source: [[annotation-esiliculosus_genome]]
 +
*** Assignment: EC-NUMBER
 +
** Source: [[orthology-aragem]]
 +
* Gene: [[Ec-27_005710]]
 +
** Source: [[annotation-esiliculosus_genome]]
 +
*** Assignment: GO-TERM
 +
== Pathways  ==
 +
* [[PWY-922]], mevalonate pathway I: [http://metacyc.org/META/NEW-IMAGE?object=PWY-922 PWY-922]
 +
** '''7''' reactions found over '''7''' reactions in the full pathway
 +
* [[PWY-6174]], mevalonate pathway II (archaea): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6174 PWY-6174]
 +
** '''5''' reactions found over '''7''' reactions in the full pathway
 +
* [[PWY-7391]], isoprene biosynthesis II (engineered): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7391 PWY-7391]
 +
** '''7''' reactions found over '''8''' reactions in the full pathway
 +
* [[PWY-7524]], mevalonate pathway III (archaea): [http://metacyc.org/META/NEW-IMAGE?object=PWY-7524 PWY-7524]
 +
** '''4''' reactions found over '''8''' reactions in the full pathway
 +
== Reconstruction information  ==
 +
* Category: [[orthology]]
 +
** Source: [[orthology-aragem]]
 +
*** Tool: [[pantograph]]
 +
* Category: [[annotation]]
 +
** Source: [[annotation-esiliculosus_genome]]
 +
*** Tool: [[pathwaytools]]
 
== External links  ==
 
== External links  ==
−
* CAS : 97-65-4
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* RHEA:
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* PUBCHEM:
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** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=15989 15989]
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** [http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=5459996 5459996]
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* LIGAND-RXN:
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* HMDB : HMDB02092
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** [http://www.genome.jp/dbget-bin/www_bget?R02082 R02082]
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* LIGAND-CPD:
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* UNIPROT:
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** [http://www.genome.jp/dbget-bin/www_bget?C00490 C00490]
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** [http://www.uniprot.org/uniprot/P16393 P16393]
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* CHEMSPIDER:
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** [http://www.uniprot.org/uniprot/P14891 P14891]
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** [http://www.chemspider.com/Chemical-Structure.4573697.html 4573697]
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** [http://www.uniprot.org/uniprot/P16237 P16237]
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* CHEBI:
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** [http://www.uniprot.org/uniprot/P20715 P20715]
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** [http://www.ebi.ac.uk/chebi/searchId.do?chebiId=17240 17240]
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** [http://www.uniprot.org/uniprot/Q59468 Q59468]
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* METABOLIGHTS : MTBLC17240
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** [http://www.uniprot.org/uniprot/Q01237 Q01237]
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{{#set: smiles=C=C(C(=O)[O-])CC([O-])=O}}
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** [http://www.uniprot.org/uniprot/Q61671 Q61671]
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{{#set: inchi key=InChIKey=LVHBHZANLOWSRM-UHFFFAOYSA-L}}
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** [http://www.uniprot.org/uniprot/Q944T9 Q944T9]
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{{#set: common name=itaconate}}
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** [http://www.uniprot.org/uniprot/Q9S9C2 Q9S9C2]
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{{#set: molecular weight=128.084    }}
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** [http://www.uniprot.org/uniprot/Q9S999 Q9S999]
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{{#set: common name=propylenedicarboxylic acid|methylenebutanedioic acid|2-propene-1,2-dicarboxylic acid|methylenesuccinic acid|itaconic acid|2-methylsuccinate}}
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** [http://www.uniprot.org/uniprot/Q9S998 Q9S998]
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{{#set: consumed by=RXN-8988}}
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** [http://www.uniprot.org/uniprot/Q9S997 Q9S997]
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** [http://www.uniprot.org/uniprot/P04035 P04035]
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** [http://www.uniprot.org/uniprot/P00347 P00347]
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** [http://www.uniprot.org/uniprot/P29058 P29058]
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** [http://www.uniprot.org/uniprot/P29057 P29057]
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** [http://www.uniprot.org/uniprot/Q12577 Q12577]
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** [http://www.uniprot.org/uniprot/Q12649 Q12649]
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** [http://www.uniprot.org/uniprot/Q00583 Q00583]
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** [http://www.uniprot.org/uniprot/Q01559 Q01559]
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** [http://www.uniprot.org/uniprot/P48022 P48022]
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** [http://www.uniprot.org/uniprot/Q43825 Q43825]
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** [http://www.uniprot.org/uniprot/Q43826 Q43826]
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** [http://www.uniprot.org/uniprot/P14773 P14773]
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** [http://www.uniprot.org/uniprot/Q7M4W2 Q7M4W2]
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** [http://www.uniprot.org/uniprot/Q7M4W1 Q7M4W1]
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** [http://www.uniprot.org/uniprot/Q7M4W4 Q7M4W4]
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** [http://www.uniprot.org/uniprot/Q7M4W3 Q7M4W3]
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** [http://www.uniprot.org/uniprot/P48019 P48019]
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** [http://www.uniprot.org/uniprot/Q41454 Q41454]
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** [http://www.uniprot.org/uniprot/Q42506 Q42506]
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** [http://www.uniprot.org/uniprot/Q41455 Q41455]
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** [http://www.uniprot.org/uniprot/Q41456 Q41456]
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** [http://www.uniprot.org/uniprot/Q41458 Q41458]
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** [http://www.uniprot.org/uniprot/P48020 P48020]
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** [http://www.uniprot.org/uniprot/Q9FS01 Q9FS01]
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** [http://www.uniprot.org/uniprot/Q42466 Q42466]
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** [http://www.uniprot.org/uniprot/O48624 O48624]
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** [http://www.uniprot.org/uniprot/O04188 O04188]
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** [http://www.uniprot.org/uniprot/O24594 O24594]
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** [http://www.uniprot.org/uniprot/Q41438 Q41438]
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** [http://www.uniprot.org/uniprot/O64966 O64966]
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** [http://www.uniprot.org/uniprot/O64967 O64967]
 +
** [http://www.uniprot.org/uniprot/Q03163 Q03163]
 +
** [http://www.uniprot.org/uniprot/Q39628 Q39628]
 +
** [http://www.uniprot.org/uniprot/P93514 P93514]
 +
** [http://www.uniprot.org/uniprot/O08424 O08424]
 +
{{#set: direction=REVERSIBLE}}
 +
{{#set: common name=hydroxymethylglutaryl-CoA reductase (NADPH)}}
 +
{{#set: common name=Hydroxymethylglutaryl-CoA reductase, class I/II}}
 +
{{#set: common name=Hydroxymethylglutaryl-CoA reductase, N-terminal}}
 +
{{#set: ec number=EC-1.1.1.34}}
 +
{{#set: gene associated=Ec-03_000570|Ec-03_000580|Ec-08_002990|Ec-27_005710}}
 +
{{#set: in pathway=PWY-922|PWY-6174|PWY-7391|PWY-7524}}
 +
{{#set: reconstruction category=orthology|annotation}}
 +
{{#set: reconstruction source=annotation-esiliculosus_genome|orthology-aragem}}
 +
{{#set: reconstruction tool=pantograph|pathwaytools}}

Latest revision as of 20:31, 21 March 2018

Reaction 1.1.1.34-RXN

  • direction:
    • REVERSIBLE
  • common name:
    • hydroxymethylglutaryl-CoA reductase (NADPH)
    • Hydroxymethylglutaryl-CoA reductase, class I/II
    • Hydroxymethylglutaryl-CoA reductase, N-terminal
  • ec number:
  • Synonym(s):

Reaction Formula

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

Pathways

  • PWY-922, mevalonate pathway I: PWY-922
    • 7 reactions found over 7 reactions in the full pathway
  • PWY-6174, mevalonate pathway II (archaea): PWY-6174
    • 5 reactions found over 7 reactions in the full pathway
  • PWY-7391, isoprene biosynthesis II (engineered): PWY-7391
    • 7 reactions found over 8 reactions in the full pathway
  • PWY-7524, mevalonate pathway III (archaea): PWY-7524
    • 4 reactions found over 8 reactions in the full pathway

Reconstruction information

External links






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