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	Ec number	Reconstruction category	Reconstruction tool	Reconstruction source	Gene associated	In pathway
3-OXOACYL-ACP-SYNTH-BASE-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-2.3.1.41	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network	Tiso gene 19302 Tiso gene 136 Tiso gene 14485 Tiso gene 13394 Tiso gene 5939 Tiso gene 135 Tiso gene 10876 Tiso gene 500 Tiso gene 15991	PWY-5965 PWY-5966 FASYN-INITIAL-PWY PWY-7388
3-OXOACYL-ACP-SYNTH-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-2.3.1.41	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 136 Tiso gene 15991 Tiso gene 14485 Tiso gene 135 Tiso gene 13394 Tiso gene 500 Tiso gene 5939 Tiso gene 10876 Tiso gene 19302	FASYN-ELONG-PWY
3.1.1.23-RXN	EC-3.1.1.23	Annotation	Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation	Tiso gene 12375	LIPAS-PWY
3.1.1.64-RXN	EC-3.1.1.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 1538 Tiso gene 1537 Tiso gene 9429 Tiso gene 1922 Tiso gene 2556 Tiso gene 19778 Tiso gene 12686 Tiso gene 4606 Tiso gene 4650 Tiso gene 10066 Tiso gene 17029 Tiso gene 16518 Tiso gene 11351
3.1.3.16-RXN	EC-3.1.3.16	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 452 Tiso gene 2190 Tiso gene 7036 Tiso gene 3751 Tiso gene 15176 Tiso gene 17314 Tiso gene 5305 Tiso gene 1395 Tiso gene 10912 Tiso gene 7035 Tiso gene 2578 Tiso gene 15559 Tiso gene 13371 Tiso gene 18472 Tiso gene 19603 Tiso gene 16524 Tiso gene 15788 Tiso gene 16525 Tiso gene 20309 Tiso gene 4137 Tiso gene 12379 Tiso gene 4164 Tiso gene 2034 Tiso gene 11870 Tiso gene 453 Tiso gene 18502 Tiso gene 12989 Tiso gene 1840
3.1.3.46-RXN	EC-3.1.3.46	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Orthology-athaliana Annotation-experimental annotation Annotation-in-silico annotation	Tiso gene 15398 Tiso gene 2100 Tiso gene 893 Tiso gene 892	PWY66-423
3.1.4.11-RXN	EC-3.1.4.11	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 7561 Tiso gene 12020 Tiso gene 12019	PWY-6367 PWY-6351 PWY-7039 LIPASYN-PWY
3.2.1.106-RXN	EC-3.2.1.106	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 12662
3.2.1.21-RXN	EC-3.2.1.21	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 6187 Tiso gene 15066 Tiso gene 3467 Tiso gene 8669 Tiso gene 5836 Tiso gene 6188 Tiso gene 2843 Tiso gene 15067 Tiso gene 6497 Tiso gene 13305 Tiso gene 13306 Tiso gene 6007 Tiso gene 10001 Tiso gene 2344
3.2.1.37-RXN	EC-3.2.1.37	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 10897
3.2.1.55-RXN	EC-3.2.1.55	Annotation	Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation	Tiso gene 14849 Tiso gene 6300 Tiso gene 10897 Tiso gene 6299
3.2.1.58-RXN	EC-3.2.1.58	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 16125
3.2.1.84-RXN	EC-3.2.1.84	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 2588
3.2.1.91-RXN	EC-3.2.1.91	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 2906	PWY-6788
3.4.11.14-RXN	EC-3.4.11.14	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 860
3.4.11.18-RXN	EC-3.4.11.18	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 5715 Tiso gene 3182 Tiso gene 4247
3.4.11.21-RXN	EC-3.4.11.21	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 9879
3.4.11.5-RXN	EC-3.4.11.5	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation	Tiso gene 6098 Tiso gene 879 Tiso gene 6057 Tiso gene 6058
3.4.11.9-RXN	EC-3.4.11.9	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation	Tiso gene 13489 Tiso gene 14456 Tiso gene 13488 Tiso gene 16185
3.4.16.5-RXN	EC-3.4.16.5	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 514
3.4.17.11-RXN	EC-3.4.17.11	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 5253
3.4.21.53-RXN	EC-3.4.21.53	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 4277 Tiso gene 7032
3.4.21.92-RXN	EC-3.4.21.92	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 10324 Tiso gene 11705 Tiso gene 10005 Tiso gene 999
3.4.24.11-RXN	EC-3.4.24.11	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 15103
3.4.24.64-RXN	EC-3.4.24.64	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation	Tiso gene 5405
3.4.25.1-RXN	EC-3.4.25.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 19087 Tiso gene 1855 Tiso gene 16496 Tiso gene 11443 Tiso gene 18135 Tiso gene 3310 Tiso gene 11901 Tiso gene 5953 Tiso gene 7332 Tiso gene 20415 Tiso gene 2549
3.5.1.52-RXN	EC-3.5.1.52	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation	Tiso gene 18090 Tiso gene 18091
3.5.1.98-RXN	EC-3.5.1.98	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 10459 Tiso gene 17880 Tiso gene 17340 Tiso gene 12946 Tiso gene 12131 Tiso gene 16490 Tiso gene 3315 Tiso gene 17377 Tiso gene 275 Tiso gene 18096 Tiso gene 727 Tiso gene 19850 Tiso gene 18920
3.6.3.8-RXN	EC-3.6.3.8	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 10760
3.6.4.6-RXN	EC-3.6.4.6	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 1145
3PGAREARR-RXN	EC-5.4.2.12	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 16271 Tiso gene 5468 Tiso gene 14530 Tiso gene 7201 Tiso gene 20311 Tiso gene 2365 Tiso gene 10516 Tiso gene 16754 Tiso gene 9922 Tiso gene 2667 Tiso gene 15391 Tiso gene 2841 Tiso gene 15048 Tiso gene 14212 Tiso gene 9923 Tiso gene 14664	PWY-1042 P341-PWY PWY-2221 GLUCONEO-PWY GLYCOLYSIS PWY-6901 PWY-7218 P124-PWY PWY-6886 PWY-5723 PWY-6142 PWY-5484 PWY-7124 PWY-7003
4.2.1.58-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Manual Annotation	Pathwaytools	Annotation-experimental annotation Manual-primary network Annotation-in-silico annotation	Tiso gene 6884 Tiso gene 13394 Tiso gene 136 Tiso gene 500 Tiso gene 135 Tiso gene 10876	PWY-5971 PWY-5994 PWY-7388
4.2.1.59-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation Orthology-synechocystis	Tiso gene 500 Tiso gene 13394 Tiso gene 10876 Tiso gene 135 Tiso gene 6884 Tiso gene 6885 Tiso gene 136	PWY-5971 PWY-5994
4.2.1.61-RXN	EC-2.3.1.86 EC-2.3.1.85 EC-4.2.1.59	Manual Annotation	Pathwaytools	Annotation-in-silico annotation Manual-primary network Annotation-experimental annotation	Tiso gene 136 Tiso gene 13394 Tiso gene 10876 Tiso gene 500 Tiso gene 6884 Tiso gene 135	PWY-5971 PWY-5994
4.2.99.18-RXN	EC-4.2.99.18	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 1280 Tiso gene 5102 Tiso gene 14609 Tiso gene 6558 Tiso gene 17380
5.3.4.1-RXN	EC-5.3.4.1	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 15704 Tiso gene 475 Tiso gene 4246 Tiso gene 4244 Tiso gene 7350 Tiso gene 14313
5.99.1.2-RXN	EC-5.99.1.2	Orthology Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 3425 Tiso gene 1740 Tiso gene 5748 Tiso gene 5749 Tiso gene 14333 Tiso gene 200 Tiso gene 10513 Tiso gene 5035 Tiso gene 1739 Tiso gene 5036 Tiso gene 1291 Tiso gene 5747 Tiso gene 6569
5.99.1.3-RXN	EC-5.99.1.3	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Annotation-in-silico annotation Orthology-esiliculosus	Tiso gene 12629 Tiso gene 6569 Tiso gene 828 Tiso gene 3610 Tiso gene 3396 Tiso gene 829 Tiso gene 3728 Tiso gene 1291 Tiso gene 3374
6-PHOSPHOFRUCTO-2-KINASE-RXN	EC-2.7.1.105	Orthology Annotation	Pantograph Pathwaytools	Orthology-creinhardtii Orthology-athaliana Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation	Tiso gene 2100 Tiso gene 892 Tiso gene 804 Tiso gene 893 Tiso gene 15398	PWY66-423
6.3.5.6-RXN	EC-6.3.5.6	Orthology Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 12219 Tiso gene 9908	PWY490-4
6.3.5.7-RXN	EC-6.3.5.7	Annotation	Pathwaytools	Annotation-experimental annotation	Tiso gene 12219	PWY-5921
6PFRUCTPHOS-RXN	EC-2.7.1.11	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Manual-primary network Orthology-creinhardtii	Tiso gene 5733 Tiso gene 596	PWY-1042 GLYCOLYSIS PWY-7385 PWY-1861 ANAGLYCOLYSIS-PWY PWY-5484
6PGLUCONOLACT-RXN	EC-3.1.1.31	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-athaliana Manual-primary network Orthology-creinhardtii	Tiso gene 10799 Tiso gene 5901 Tiso gene 15950 Tiso gene 8585 Tiso gene 20412	P122-PWY RUMP-PWY OXIDATIVEPENT-PWY GLYCOLYSIS-E-D
ACETATE--COA-LIGASE-RXN	EC-6.2.1.1	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-experimental annotation Orthology-esiliculosus Annotation-in-silico annotation Orthology-synechocystis Manual-primary network Orthology-creinhardtii	Tiso gene 3617 Tiso gene 1612 Tiso gene 3616	PWY66-161 PWY66-21 PWY66-162 PWY0-1313 PWY-6672 PWY-7118
ACETOACETATE-DECARBOXYLASE-RXN	EC-4.1.1.4	Annotation	Pathwaytools	Annotation-in-silico annotation Annotation-experimental annotation		PWY66-367 PWY-5451 PWY-6588 PWY-7466 PWY-6876
ACETOLACTREDUCTOISOM-RXN	EC-1.1.1.86	Orthology Manual Annotation	Pantograph Pathwaytools	Manual-primary network Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 10173	VALSYN-PWY PWY-7111
ACETOLACTSYN-RXN	EC-2.2.1.6	Manual Annotation	Pathwaytools	Manual-primary network Annotation-experimental annotation	Tiso gene 11362	VALSYN-PWY PWY-7111 PWY-6389 PWY-5938 PWY-5939
ACETOOHBUTREDUCTOISOM-RXN	EC-1.1.1.86	Orthology Manual Annotation	Pantograph Pathwaytools	Manual-primary network Annotation-experimental annotation Orthology-esiliculosus	Tiso gene 10173	PWY-5103 ILEUSYN-PWY
ACETOOHBUTSYN-RXN	EC-2.2.1.6	Manual Annotation	Pathwaytools	Manual-primary network Annotation-experimental annotation	Tiso gene 11362	PWY-5103 ILEUSYN-PWY PWY-5101 PWY-5104
ACETYL-COA-CARBOXYLTRANSFER-RXN	EC-6.4.1.2	Orthology Manual Annotation	Pantograph Pathwaytools	Annotation-in-silico annotation Orthology-athaliana Annotation-experimental annotation Manual-primary network Orthology-esiliculosus	Tiso gene 3800 Tiso gene 5029 Tiso gene 2812 Tiso gene 7965	PWY-7388 PWY-6722 PWY-5743 PWY-5744 PWY-5789 PWY-6679 PWY-4381

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