View source for ISOCIT-CLEAV-RXN

[[Category:Reaction]]
== Reaction [http://metacyc.org/META/NEW-IMAGE?object=ISOCIT-CLEAV-RXN ISOCIT-CLEAV-RXN] ==
* direction:
** REVERSIBLE
* common name:
** isocitrate_lyase
* ec number:
** [http://enzyme.expasy.org/EC/4.1.3.1 EC-4.1.3.1]
* Synonym(s):

== Reaction Formula ==
* With identifiers:
** 1 [[THREO-DS-ISO-CITRATE]][c] '''<=>''' 1 [[GLYOX]][c] '''+''' 1 [[SUC]][c]
* With common name(s):
** 1 D-threo-isocitrate[c] '''<=>''' 1 glyoxylate[c] '''+''' 1 succinate[c]

== Genes associated with this reaction  ==
Genes have been associated with this reaction based on different elements listed below.
* Gene: [[Tiso_gene_14008]]
** Source: [[annotation-in-silico_annotation]]
*** Assignment: AUTOMATED-NAME-MATCH
** Source: [[annotation-experimental_annotation]]
*** Assignment: AUTOMATED-NAME-MATCH
** Source: [[orthology-esiliculosus]]
== Pathways  ==
* [[P105-PWY]], TCA cycle IV (2-oxoglutarate decarboxylase): [http://metacyc.org/META/NEW-IMAGE?object=P105-PWY P105-PWY]
** '''9''' reactions found over '''11''' reactions in the full pathway
* [[GLYOXYLATE-BYPASS]], glyoxylate cycle: [http://metacyc.org/META/NEW-IMAGE?object=GLYOXYLATE-BYPASS GLYOXYLATE-BYPASS]
** '''6''' reactions found over '''6''' reactions in the full pathway
* [[PWY-6969]], TCA cycle V (2-oxoglutarate:ferredoxin oxidoreductase): [http://metacyc.org/META/NEW-IMAGE?object=PWY-6969 PWY-6969]
** '''9''' reactions found over '''12''' reactions in the full pathway
== Reconstruction information  ==
* Category: [[orthology]]
** Source: [[orthology-esiliculosus]]
*** Tool: [[pantograph]]
* Category: [[annotation]]
** Source: [[annotation-experimental_annotation]]
*** Tool: [[pathwaytools]]
** Source: [[annotation-in-silico_annotation]]
*** Tool: [[pathwaytools]]
== External links  ==
* RHEA:
** [http://www.ebi.ac.uk/rhea/reaction.xhtml?id=13245 13245]
* PIR:
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=A41338 A41338]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=I40713 I40713]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=JA0155 JA0155]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=JC6182 JC6182]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=S26857 S26857]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=S26858 S26858]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=S39953 S39953]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=S52819 S52819]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=S77654 S77654]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T04115 T04115]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T06353 T06353]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T07631 T07631]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T07632 T07632]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T08046 T08046]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T09774 T09774]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T09779 T09779]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=T11209 T11209]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=WZBYI WZBYI]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=WZCKI WZCKI]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=WZCNIU WZCNIU]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=WZCSI WZCSI]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=WZECIC WZECIC]
** [http://pir.georgetown.edu/cgi-bin/nbrfget?uid=WZRPI WZRPI]
* LIGAND-RXN:
** [http://www.genome.jp/dbget-bin/www_bget?R00479 R00479]
* UNIPROT:
** [http://www.uniprot.org/uniprot/P28467 P28467]
** [http://www.uniprot.org/uniprot/P42449 P42449]
** [http://www.uniprot.org/uniprot/P20699 P20699]
** [http://www.uniprot.org/uniprot/O13439 O13439]
** [http://www.uniprot.org/uniprot/P28299 P28299]
** [http://www.uniprot.org/uniprot/Q12031 Q12031]
** [http://www.uniprot.org/uniprot/P46831 P46831]
** [http://www.uniprot.org/uniprot/O24588 O24588]
** [http://www.uniprot.org/uniprot/P49297 P49297]
** [http://www.uniprot.org/uniprot/P45456 P45456]
** [http://www.uniprot.org/uniprot/P45457 P45457]
** [http://www.uniprot.org/uniprot/Q39577 Q39577]
** [http://www.uniprot.org/uniprot/Q41084 Q41084]
** [http://www.uniprot.org/uniprot/Q43097 Q43097]
** [http://www.uniprot.org/uniprot/P28240 P28240]
** [http://www.uniprot.org/uniprot/P20014 P20014]
** [http://www.uniprot.org/uniprot/P17069 P17069]
** [http://www.uniprot.org/uniprot/P15479 P15479]
** [http://www.uniprot.org/uniprot/P0A9G6 P0A9G6]
** [http://www.uniprot.org/uniprot/P25248 P25248]
{{#set: direction=REVERSIBLE}}
{{#set: common name=isocitrate_lyase}}
{{#set: ec number=EC-4.1.3.1}}
{{#set: gene associated=Tiso_gene_14008}}
{{#set: in pathway=P105-PWY|GLYOXYLATE-BYPASS|PWY-6969}}
{{#set: reconstruction category=orthology|annotation}}
{{#set: reconstruction source=annotation-experimental_annotation|annotation-in-silico_annotation|orthology-esiliculosus}}
{{#set: reconstruction tool=pantograph|pathwaytools}}