2OXOGLUTDECARB-RXN

Reaction 2OXOGLUTDECARB-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • dihydrolipoamide dehydrogenase
  • 2-oxoglutarate dehydrogenase, E1 component
• ec number:
  • EC-1.2.4.2
• Synonym(s):
  • Oxoglutarate decarboxylase
  • 2-oxoglutarate decarboxylation

Reaction Formula

• With identifiers:
  • 1 PROTON[c] + 1 Oxo-glutarate-dehydrogenase-lipoyl[c] + 1 2-KETOGLUTARATE[c] => 1 Oxo-glutarate-dehydro-suc-DH-lipoyl[c] + 1 CARBON-DIOXIDE[c]
• With common name(s):
  • 1 H+[c] + 1 a [2-oxoglutarate dehydrogenase E2 protein] N6-lipoyl-L-lysine[c] + 1 2-oxoglutarate[c] => 1 a [2-oxoglutarate dehydrogenase E2 protein] N6-S-succinyldihydrolipoyl-L-lysine[c] + 1 CO2[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: CHC_T00010287001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00008312001
  • Source: annotation-original_genome
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: CHC_T00008441001
  • Source: annotation-original_genome
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: CHC_T00008441001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00008312001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus

Pathways

• PWY66-398, TCA cycle III (animals): PWY66-398
  • 11 reactions found over 11 reactions in the full pathway
• PWY-5084, 2-oxoglutarate decarboxylation to succinyl-CoA: PWY-5084
  • 3 reactions found over 3 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-galdieria.sulphuraria
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-original_genome
    • Tool: pathwaytools

External links

• UNIPROT:
  • P23129
  • Q02218
  • Q60597
  • Q9JRJ8
  • P20967
  • P0AFG3
  • P20707
  • P51056
  • Q56600
  • O49541
  • Q59106
  • Q9M2T8
  • Q9ZRQ2