UBIQUITIN--PROTEIN-LIGASE-RXN

Reaction UBIQUITIN--PROTEIN-LIGASE-RXN

• direction:
  • LEFT-TO-RIGHT
• common name:
  • ubiquitin-activating enzyme E1
• ec number:
  • EC-6.2.1.45
• Synonym(s):

Reaction Formula

• With identifiers:
  • 1 Ubiquitin-C-Terminal-Glycine[c] + 1 ATP[c] + 1 Ubiquitin-activating-protein-E1-L-cys[c] => 1 S-ubiquitinyl-UAP-E1-L-cysteine[c] + 1 AMP[c] + 1 PPI[c]
• With common name(s):
  • 1 a [ubiquitin] C-terminal glycine[c] + 1 ATP[c] + 1 an [E1 ubiquitin-activating enzyme]-L-cysteine[c] => 1 an S-ubiquitinyl-[E1 ubiquitin-activating enzyme]-L-cysteine[c] + 1 AMP[c] + 1 diphosphate[c]

Genes associated with this reaction

Genes have been associated with this reaction based on different elements listed below.

• Gene: CHC_T00002999001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00003204001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00010007001
  • Source: annotation-original_genome
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: CHC_T00000387001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00006427001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00002169001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00004379001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00002451001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00010352001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00009358001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00006980001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00008502001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00006277001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00005498001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00004399001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00007651001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00000123001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00007701001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00009466001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00008644001
  • Source: annotation-original_genome
    • Assignment: AUTOMATED-NAME-MATCH
• Gene: CHC_T00003966001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00002791001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00005531001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00008443001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00008828001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00006794001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00002417001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00004279001_1
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00004299001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00009159001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00004841001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00010007001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00005520001_1
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00008644001_1
  • Source: orthology-galdieria.sulphuraria
  • Source: orthology-ectocarpus_siliculosus
• Gene: CHC_T00010346001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00003230001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00005234001_1
  • Source: orthology-galdieria.sulphuraria
• Gene: CHC_T00010031001_1
  • Source: orthology-ectocarpus_siliculosus

Pathways

• PWY-7511, protein ubiquitylation: PWY-7511
  • 9 reactions found over 9 reactions in the full pathway

Reconstruction information

• Category: orthology
  • Source: orthology-galdieria.sulphuraria
    • Tool: pantograph
  • Source: orthology-ectocarpus_siliculosus
    • Tool: pantograph
• Category: annotation
  • Source: annotation-original_genome
    • Tool: pathwaytools

External links

• LIGAND-RXN:
  • R03876
• UNIPROT:
  • P22314
  • P49459
  • P62256
  • P63146
  • P28263
  • Q02053
  • P62257
  • P61088
  • P63279
  • P19812
  • P21734
  • P25869
  • P31254
  • P15731
  • P15732
  • P29340
  • P35133
  • P35134
  • P35132
  • P33296
  • P22515
  • P39940
  • P42748
  • P42750
  • P42749
  • P42747
  • P50623
  • Q42973
  • P40984
  • Q92462
  • Q42540
  • P93028
  • P93393
  • P31252
  • P52486
  • Q9YGM6
  • O42646
  • O15979
  • P23566
  • Q96PU5
  • P27949